Your Brain's Health Story — Written Before Symptoms Appear
The Precision Prevention Blueprint maps your cognitive health today so you can protect it tomorrow.
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Currently serving South Florida — call us to discuss if you're elsewhere.
Why Prevention Matters — Now
Decades of research have converged on a powerful insight: the path to lasting cognitive health starts long before any symptoms appear.
of dementia cases may be preventable or delayable
Lancet Commission, 2024
greater cognitive improvement with multidomain lifestyle intervention
FINGER Trial, The Lancet, 2015
people in the United States with undiagnosed Mild Cognitive Impairment
AAN
silent phase before symptoms appear — your window to act
Alzheimer's Research Consensus
The Prevention Window
Your brain undergoes measurable changes 10–20 years before any memory symptoms appear. This silent phase is the optimal window for intervention — and most people never even know it's open.
The FINGER & POINTER Evidence
The landmark FINGER study (The Lancet, 2015) was the world's first randomized controlled trial proving that multidomain lifestyle intervention can meaningfully protect cognitive function. The U.S. POINTER study (2025) confirmed this in diverse American populations.
Up to 45% Is Modifiable
The Lancet Commission (2024) estimates that up to 45% of dementia cases worldwide may be preventable or delayable through addressing modifiable risk factors — including exercise, diet, sleep, and cardiovascular health.
This information is educational and based on published research. It is not intended as medical advice.
The Precision Difference
Five integrated pillars of assessment give you a complete picture of your brain health — going far deeper than any standard evaluation.
Advanced MRI Brain Imaging
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Blood Biomarker Panel
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Advanced Cognitive Testing
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Personal & Family History
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Lifestyle & Environmental Factors
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Your Roadmap to a
Sharper Future
The Precision Prevention Blueprint is a comprehensive, personalized wellness report that translates complex clinical data into clear, actionable insight.
Current Brain Health Score
A composite snapshot across all 5 pillars
Regional Brain Volume Analysis
MRI findings with age-matched comparisons
Biomarker Breakdown
What your blood results mean for your brain
Cognitive Performance Profile
Strengths and areas of opportunity
Personalized Risk Stratification
Which modifiable factors are your priority
Evidence-Based Action Plan
Lifestyle, nutrition, exercise, cognitive training
Monitoring Roadmap
Timeline for re-assessment and progress tracking
Note: The Blueprint is an educational wellness report prepared to help you understand your current brain health status and plan for the future. It is not a covered medical service.
Currently available at our Boca Raton, FL location.
Currently serving South Florida — call us to discuss if you're elsewhere.
Led by a Neurologist
Thema Brain Health is founded on clinical expertise — not wellness trends. Every assessment protocol is designed and overseen by a board-eligible neurologist with decades of frontline experience.
Dr. Lorin Graef, M.D.
Chief Medical Officer · Thema Brain Health
Dr. Graef is a neurologist with over 25 years of experience treating patients with cognitive disorders, Alzheimer’s disease, and memory disorders. He trained at Brown University, Stanford Medical School, and completed his postgraduate training at Johns Hopkins University.
At Thema, Dr. Graef oversees all clinical protocols — from advanced brain imaging and biomarker analysis to Alzheimer’s infusion therapies including Leqembi and Kisunla.
Training
Brown University · Stanford Medical School · Johns Hopkins
Specialty
Neurology — Cognitive Disorders & Alzheimer's Disease
Experience
25+ years treating patients with cognitive disorders
Take the Brain Health Quiz
7 questions. 2 minutes. Get a personalized Prevention Health Profile based on your lifestyle, habits, and history.
Important: This quiz is for educational and wellness purposes only. It is not a medical assessment, does not establish a patient-provider relationship, and should not be used as a substitute for professional medical advice.
The People Behind the Blueprint
Founder of MDVIP, the country's largest concierge medicine company. Over 30 years of physician experience with expertise in preventive healthcare and medical innovation.
Rob Colton, M.D.
Chairman, Thema Brain Health
Founder, MDVIP
Previously founded Taithera, a biotechnology company. MBA from Columbia University and BA from Trinity College with extensive healthcare industry experience.
Seth Harlem
CEO, Thema Brain Health
25+ years treating cognitive disorders. Graduate of Brown University and Stanford Medical School. Trained at Johns Hopkins.
Lorin Graef, M.D.
Chief Medical Officer, Thema Brain Health
Board Certified Neurologist
Experienced entrepreneur and attorney. Former attorney with Cleary Gottlieb Steen & Hamilton LLP. JD and BA from University of Pennsylvania.
Sam Lehr
Chief Strategy Officer, Thema Brain Health
Board-Certified Acute Care NP specializing in Neurology. MSN from Rush University, BSN from University of Wisconsin.
Nicole Hughes, APRN
Neurology Nurse Practitioner
Reginee Bromson, APRN is a board-certified nurse practitioner at Thema Brain Health specializing in preventive neurology, cognitive decline risk reduction, personalized brain health protocols, and general neurology.
Reginee Bromson, APRN
Neurology Nurse Practitioner
Grounded in peer-reviewed research
The Lancet
FINGER Trial, 2015 · Lancet Commission, 2024
Alzheimer's Association
Research & Prevention
NIH / NIA
National Institute on Aging
FINGERS Network
World-Wide FINGERS, 30+ Countries
Common Questions
Your Brain Health Window Is Open Now
The best time to understand your brain health is before you need to.
Currently serving South Florida — call us to discuss if you're elsewhere.